Antibiotic Usage Essay -- Biology, DNA

This optimism has been dissipated long before the 20th century when the proliferation of antibiotic resistance bacteria became evident as Fleming predicted earlier. With the rapid development of infectious disease associated with antibiotic resistance forced us to change the way we view disease and the way we treat patients. However, antibiotic use has not been without consequence and several factors had contributed to the development of resistance. Some resistances are due to spontaneous mutation and these mutations are for select antibiotic resistance whilst other bacteria tend to steal the deoxyribonucleic acid (DNA) from their counterparts who are already familiar with antibiotics (Mims, 2004; Tenover, 2006). Antibiotic remained effective against most bacterial infection, however these bacterial cells develop resistance and continue to divide resulting in a resistant population and some are no longer effective against infectious disease that was killed few years ago (Levy, 2000). The impact of antibiotic resistance could lead to more infectious diseases that are hard to treat and could result in a global threat making it difficult as mutation and evolutionary pressure cause increase in antibiotic resistance (Strelkauskas et al, 2010). Antibiotics are extremely important medicine but unfortunately bacteria become resistant make it problematic as antibiotic resistance had posed problem around the world people continued to travel and modern technology and sociology exacerbated the development of resistant strains, these strains are transferred from infected people causing a repeat in cycle as they moved from one place to the next (WHO, 2001). Increased globalisation is responsible for res istance, in large overpopulat... ...odified penicillin binding proteins. Some resistant bacteria could be dangerous for example; MRSA and the vancomycin resistant staphylococcus auerus that are virulent in human pathogens (Strelkauskas, 2010) by reducing the permeability of their membranes as a way of keeping out antibiotic by turning off production of porin and other proteins (Weston, 2008), for example; the multi-drug resistant mycobacterium tuberculosis. In pathogens such as Escherichia coli and staphylococcus aureus, efflux pumps played a major role in multi-drug resistance likewise Klebsiella species becoming resistance and other bacteria producing enzymes from Extended Spectrum Beta-lactamase (Livermore and Hawley, 2005; Tenover, 2006) also multi-drug resistance antibiotics Acinetobacter Baumanii and the New Delhi Metallo-1(NDM-1) causing havoc amongst the healthcare setting (HPA, 2010).